Ethnicity

HVSI polymorphism indicates multiple origins of mtDNA in the Hazarewal population of Northern Pakistan

N. Akbar, Ahmad, H., Nadeem, M. S., Hemphill, B. E., Muhammad, K., Ahmad, W., Ilyas, M., Akbar, N., Ahmad, H., Nadeem, M. S., Hemphill, B. E., Muhammad, K., Ahmad, W., and Ilyas, M., “HVSI polymorphism indicates multiple origins of mtDNA in the Hazarewal population of Northern Pakistan”, vol. 15, p. -, 2016.

Mitochondrial DNA (mtDNA) is an important tool used to explore ethnogenetics and the evolutionary history of human populations. In this study, hypervariable segment I (HVSI) from mtDNA was analyzed to establish the genetic lineage of the Hazarewal populations residing in the Mansehra and Abbottabad districts of Northern Pakistan. HVSI was extracted from genetic specimens obtained from 225 unrelated male and female individuals belonging to seven distinct Pakistani ethnic groups (31 Abbassis, 44 Awans, 38 Gujars, 16 Jadoons, 23 Karlals, 33 Syeds, and 40 Tanolis).

Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis

S. Denden, Bouden, B., A. Khelil, H., Ben Chibani, J., Hamdaoui, M. H., Denden, S., Bouden, B., A. Khelil, H., Ben Chibani, J., Hamdaoui, M. H., Denden, S., Bouden, B., A. Khelil, H., Ben Chibani, J., and Hamdaoui, M. H., “Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis”, vol. 15, p. -, 2016.

The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial. We conducted a meta-analysis to clarify this potential association. Twelve studies were selected from articles retrieved from the and Google Scholar databases, and the data were analyzed to determine the odds ratio (OR) of genotypes AA (conferring fast caffeine metabolism) vs AC + CC (conferring slow caffeine metabolism).

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