Ethnicity

Interethnic variation of the MMP-9 microsatellite in Amerindian and Mexican Mestizo populations: considerations for genetic association studies

R. Camacho-Mejorado, Noris, G., Santana, C., Magaña, J. J., Majluf-Cruz, A., Arellano-Galindo, J., De la Peña, A., Hernández-Juárez, J., Calderón-Aranda, E. S., Meraz-Ríos, M. A., and Gómez, R., Interethnic variation of the MMP-9 microsatellite in Amerindian and Mexican Mestizo populations: considerations for genetic association studies, vol. 14, pp. 2929-2939, 2015.

We studied the interethnic variation of the MMP-9 microsatellite in the Mestizo and Amerindian populations using blood samples collected from 435 healthy unrelated individuals from the Central Valley of Mexico. DNA samples were genotyped using the -90 (CA)12-27 repeat near the MMP transcriptional start site using capillary electrophoresis. Our data were compared with those from African, Asian, and European populations (N = 729). Both Mestizo and Amerindian populations were in Hardy-Weinberg equilibrium (P ≥ 0.05).

A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil

A. V. C. Coelho, Moura, R. R., Cavalcanti, C. A. J., Guimarães, R. L., Sandrin-Garcia, P., Crovella, S., and Brandão, L. A. C., A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil, vol. 14, pp. 2876-2884, 2015.

Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples’ genetic background. The present study aimed to use a minimum quantity of markers, while retaining full potential to estimate ancestries.

Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico

G. Jaramillo-Rangel, Ortega-Martínez, M., Cerda-Flores, R. M., and Barrera-Saldaña, H. A., Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico, vol. 14. pp. 6465-6471, 2015.

Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer.

Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population

M. D. Bazzi, Nasr, F. A., Alanazi, M. S., Alamri, A., Turjoman, A. A., Moustafa, A. S., Alfadda, A. A., Pathan, A. A. K., and Parine, N. R., Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population, vol. 13, pp. 10194-10203, 2014.

Recent genome wide association studies identified many loci in several genes that have been consistently associated with type 2 diabetes mellitus in various ethnic populations. Among the genes that were most strongly associated with diabetes were fat mass- and obesity-associated, melanocortin 4 receptor, solute carrier family 30 member 8 (SLC30A8), and a member of the potassium voltage-gated channels.

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