Estrogen receptors

Roles of ERα and ERβ in estrogen-induced DDP chemoresistance in non-small cell lung cancer

N. Yu, Dou, L., Li, Y., Deng, L., Wei, X., Guo, Y., Yu, N., Dou, L., Li, Y., Deng, L., Wei, X., and Guo, Y., Roles of ERα and ERβ in estrogen-induced DDP chemoresistance in non-small cell lung cancer, vol. 15, p. -, 2016.

The role of estrogen in inducing chemoresistance is not yet fully understood. The objective of this study was to observe the relationship between estrogen levels and cellular response to chemotherapeutic drugs in non-small cell lung cancer (NSCLC) and to reveal the potential mechanisms involved. Cell viability was analyzed after pre-treating NSCLC cells with different levels of estrogen (E2), followed by treatment with an anti-tumor drug for 48 h. The roles of various estrogen receptors (ERs) were examined in vitro by blocking the activity of each ER individually.

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