Essential hypertension

Association of SNPs in the PPARγ gene and hypertension in a Mongolian population

L. Yang, Tian, R. G., Chang, P. Y., Yan, M. R., and Su, X. L., “Association of SNPs in the PPARγ gene and hypertension in a Mongolian population”, vol. 14, pp. 19295-19308, 2015.

The association of single nucleotide polymorphisms (SNPs) in PPARγ with hypertension is controversial. The aim of the present study was to clarify the contributions of PPARγ genetic variants to hypertension through an association study. A total of 414 unrelated Mongolian herdsmen and 524 Han farmers were included in this study. Fourteen intronic SNPs were analyzed and genotyped using a polymerase chain reaction/ligase detection reaction assay.

Relationship between EPHX2 gene polymorphisms and essential hypertension in Uygur, Kazakh, and Han

X. L. Zhu, Wang, L., Wang, Z., Chen, S. Z., Zhang, W. Q., and Ma, M. M., “Relationship between EPHX2 gene polymorphisms and essential hypertension in Uygur, Kazakh, and Han”, vol. 14, pp. 3474-3480, 2015.

We investigated the association between rs751141 polymorphisms in the EPHX2 gene and essential hypertension in Uygur, Kazakh, and Han subjects in Xinjiang, China. A total of 302 essential hypertensive patients in Uygur, 267 in Kazakh, and 368 in Han, as well as 323 normotensive controls in Uygur, 284 in Kazakh, and 348 in Han were enrolled in this study. The TaqMan assay was used to detect the rs751141 G/A gene polymorphism in EPHX2.

Association between G-217A polymorphism in the AGT gene and essential hypertension: a meta-analysis

R. Yao, Du, Y. Y., Zhang, Y. Z., Chen, Q. H., Zhao, L. S., and Li, L., “Association between G-217A polymorphism in the AGT gene and essential hypertension: a meta-analysis”, vol. 14, pp. 5527-5534, 2015.

Numerous studies have evaluated the association between the angiotensinogen (AGT) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature search of the Google Scholar, PubMed, and China National Knowledge Infrastructure databases for relevant studies that examined the G-217A polymorphism and risk of essential hypertension.

Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

Y. Yang, Xu, J. R., Liu, X. M., Zhou, J., Yang, B., Li, M., and Wang, Y. J., “Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population”, vol. 13, pp. 1212-1219, 2014.

In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects with EH of Chinese Hui ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis.

Risk factors for the development of essential hypertension in a Mongolian population of China: a case-control study

N. Dalai, Cui, H., Yan, M., Rile, G., Li, S., and Su, X., “Risk factors for the development of essential hypertension in a Mongolian population of China: a case-control study”, vol. 13, pp. 3283-3291, 2014.

Lifestyle, habits, diet, and genetics are all important factors associated with the prevalence of hypertension. Many association studies have been performed in the Chinese Han population, whereas data explaining the high prevalence of hypertension in the Mongolian population remain scarce. In the present study, we aimed to determine the factors associated with the development of essential hypertension in Mongolians. A total of 194 hypertensive cases and 201 controls from Dongwu County were enrolled in the study.

Correlation between the NPPB gene promoter c.-1298 G/T polymorphism site and pulse pressure in the Chinese Han population

K. Zeng, Wu, X. D., Cai, H. D., Gao, Y. G., Li, G., Liu, Q. C., Gao, F., Chen, J. H., and Lin, C. Z., “Correlation between the NPPB gene promoter c.-1298 G/T polymorphism site and pulse pressure in the Chinese Han population”, vol. 13, pp. 3265-3274, 2014.

The aim of this study was to investigate the correlation between the natriuretic peptide precursor B (NPPB) gene single nucleotide polymorphism (SNP) c.-1298 G/T and pulse pressure (PP) of the Chinese Han population and the association between genotype and clinical indicators of hypertension. Peripheral blood was collected from 180 unrelated patients with hypertension and 540 healthy volunteers (control group), and DNA was extracted to amplify the 5'-flanking region and 2 exons of the NPPB gene by polymerase chain reaction; the fragment was sequenced after purification.

Interaction of six candidate genes in essential hypertension

D. C. Hu, Zhao, X. L., Shao, J. C., Wang, W., Qian, J., Chen, A. H., Zhang, H. Q., Guo, H., Jiang, J., and Li, H. Y., “Interaction of six candidate genes in essential hypertension”, vol. 13, pp. 8385-8395, 2014.

We explored the interaction of 6 candidate genetic mutations in essential hypertension (EH). The mutations AGT M235T, ACE I/D, eNOS Glu298Asp, ET-2 A985G, ANP T2238C, and NPRC A-55C were detected using a genechip microarray in 100 patients with EH and 97 controls from the Han population living in the Yunnan Province of China. Risks of EH were evaluated with respect to a combination of these genotypes. Interactions were analyzed using multifactor dimensionality reduction (MDR). P values were corrected using Bonferroni’s adjustment.

Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis

F. Zhang, Yang, Y., Hu, D., Lei, H., and Wang, Y., “Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis”, vol. 11, pp. 3511-3517, 2012.

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls.

Polymorphisms of the angiotensin II type 1 receptor gene affect antihypertensive response to angiotensin receptor blockers in hypertensive Chinese

H. T. Gong, Ma, X. L., Chen, B. X., Xu, X. Y., Li, Q., Guo, C. X., and Du, F. H., “Polymorphisms of the angiotensin II type 1 receptor gene affect antihypertensive response to angiotensin receptor blockers in hypertensive Chinese”, vol. 12, pp. 2068-2075, 2013.

The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1 receptor are associated with blood pressure response to angiotensin II receptor blockers in hypertensive Chinese patients.

Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population

B. Yang, Xu, J. R., Liu, X. M., Yang, Y., Na, X. F., Li, M., and Wang, Y. J., “Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population”, vol. 12, pp. 3821-3829, 2013.

We investigated a possible association of polymorphism of the eNOS gene and essential hypertension in the Chinese Hui population; polymorphisms of rs2070744 (T>C), rs1799983 (G>T), rs1800780 (A>G), and rs3918181 (A>G) loci of the eNOS gene were examined. We found that the genotypic frequencies at rs1799983 and rs1800780 loci differed significantly between patients with essential hypertension and control cohorts.

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