Esophageal cancer

miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4

Y. H. Zhang, Wang, Q. Q., Li, H., Ye, T., Gao, F., Liu, Y. C., Zhang, Y. H., Wang, Q. Q., Li, H., Ye, T., Gao, F., and Liu, Y. C., miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4, vol. 15, p. -, 2016.

Radiotherapy is one of the most important treatments for esophageal cancer, but radioresistance remains a major challenge. Previous studies have shown that microRNAs (miRNAs or miRs) are involved in human cancers. miR-124 has been widely reported in various cancers and it is intimately involved in proliferation, cell cycle regulation, apoptosis, migration, and invasion of cancer cells. The aim of this study was to explore the relationship between the miR-124/cyclin-dependent kinase 4 (CDK4) axis and the radiosensitivity of esophageal cancer cells.

Effect of SNX-2112 on proliferation of esophageal cancer cells via regulation of excision repair cross-complementing 1, epidermal growth factor receptor, and p53 expression

C. Y. Li, Ren, Y. J., Li, Y. D., Li, C. Y., Ren, Y. J., and Li, Y. D., Effect of SNX-2112 on proliferation of esophageal cancer cells via regulation of excision repair cross-complementing 1, epidermal growth factor receptor, and p53 expression, vol. 15, p. -, 2016.

SNX-2112 is a potential molecular targeted therapeutic drug against esophageal cancer (EC). However, its exact mechanism of action remains to be explained. The aim of this study was to investigate the effect of SNX-2112 on excision repair cross- complementing 1 (ERCC1), epidermal growth factor receptor (EGFR), and p53, to elucidate the mechanism of action of SNX-2112 on EC. Fresh tumor sections were surgically obtained from 65 patients with EC, and the expression of ERCC1, EGFR, and p53 was determined by immunohistochemical staining.

SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population

H. Y. Li, Liu, Y. C., Bai, Y. H., Sun, M., Wang, L., Zhang, X. B., Cai, B., Li, H. Y., Liu, Y. C., Bai, Y. H., Sun, M., Wang, L., Zhang, X. B., and Cai, B., SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population, vol. 15, p. -, 2016.

The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer patients and 636 cancer-free age- and gender-matched controls using polymerase chain reaction restriction and direct sequencing.

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