Esophageal cancer

Influence of thoracic duct ligation on the lipid metabolism of patients with esophageal carcinoma after esophagectomy

J. P. Liu, Zhang, Y. H., Yang, B., Chen, Q., and Cao, L., “Influence of thoracic duct ligation on the lipid metabolism of patients with esophageal carcinoma after esophagectomy”, vol. 14, pp. 2527-2536, 2015.

The aim of this study was to determine the influence of thoracic duct ligation on the lipid metabolism of patients with esophageal carcinoma after esophagectomy. A total of 74 patients with esophageal carcinoma who underwent esophagectomy were divided into 2 groups according to whether or not their thoracic duct was ligated. Thirty-nine patients were in the thoracic duct ligation group and the other 35 assigned to the control group. Enteral feeding was through a nasojejunal tube from the 1st day to the 8th day after operation, and liquid diet was provided starting on the 6th day.

Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma

H. B. Liu, Zhu, Y., Yang, Q. C., Shen, Y., Zhang, X. J., and Chen, H., “Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma”, vol. 14, pp. 4391-4398, 2015.

We examined disintegrin and metalloproteinase 17 (ADAM17) protein expression in esophageal squamous cell carcinoma and its clinical and pathological correlated factors. Western blotting and immunohistochemistry were used to detect ADAM17 protein expression in esophageal squamous cell carcinoma and the corresponding normal esophageal mucosa in 50 cases. ADAM17 protein expression in 50 cases with esophageal squamous cells was 0.887 ± 0.174; the positive expression rate was 66% (33/50).

Association of miR-21 with esophageal cancer prognosis: a meta-analysis

S. - W. Wen, Zhang, Y. - F., Li, Y., Liu, Z. - X., Lv, H. - L., Li, Z. - H., Xu, Y. - Z., Zhu, Y. - G., and Tian, Z. - Q., “Association of miR-21 with esophageal cancer prognosis: a meta-analysis”, vol. 14, pp. 6578-6582, 2015.

The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of case, etc. from the studies included. We calculated the pooled hazard ratios (HRs) using the RevMan 5.2 software.

EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis

X. Tan, He, W. W., Wang, Y. Y., Shi, L. J., and Chen, M. W., “EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis”, vol. 13, pp. 649-659, 2014.

Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) polymorphisms and esophageal cancer risk, but the results are controversial. This study aimed to identify the association between EPHX1 (Tyr113His and His139Arg) polymorphisms and esophageal cancer risk by meta-analysis.

Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer

X. P. Huang, Zhou, W. H., and Zhang, Y. F., “Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer”, vol. 13, pp. 2107-2119, 2014.

Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual’s susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 15th, 2013. This meta-analysis was performed using the STATA 12.0 software.

Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang

L. Zhang, Sun, J., Zhang, J. Q., Yang, M., Bai, G., and Ma, X. L., “Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang”, vol. 13, pp. 5413-5425, 2014.

This study aimed to explore some useful biomarkers to focus on the diagnosis and therapy response judgment in esophageal squamous cell carcinoma in Xinjiang. We used enzyme-linked immunosorbent method and immunohistochemistry to detect the expression of VEGF, EGFR, ES, HER-2, and NF-κBp in the serum and tissue with esophageal squamous cell carcinoma, and to analyze the relationship between biomarkers and clinical pathology and curative effects. Our findings were as follows: 1.

Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis

T. - Y. Wang, Liu, S. - G., Zhao, B. - S., Qi, B., Qin, X. - G., and Yao, W. - J., “Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis”, vol. 13, pp. 5574-5581, 2014.

The aim of this study was to investigate the significance of the microRNA miR-197 expression level in relation to clinicopathological factors and prognoses of esophageal cancer (EC). MicroRNA was extracted using the Taqman® MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different prognoses, who underwent surgery. Paracancerous normal tissues were used as controls.

Overregulation of microRNA-212 in the poor prognosis of esophageal cancer patients

B. Qi, Liu, S. G., Qin, X. G., Yao, W. J., Lu, J. G., Guo, L., Wang, T. Y., Li, H. C., and Zhao, B. S., “Overregulation of microRNA-212 in the poor prognosis of esophageal cancer patients”, vol. 13, pp. 7800-7807, 2014.

There have been few reports evaluating the expression and function of the microRNA miR-212 in esophageal cancer. The aim of this study was to investigate the relationship between miR-212 expression and clinicopathological factors and prognoses of esophageal cancer. MicroRNA was extracted from 46 esophageal cancer patients using the Taqman MicroRNA assay. All patients were at the same tumor node metastasis stage, but with different prognoses, and had all undergone surgery.

Meta-analysis demonstrates association of XRCC1 genetic polymorphism Arg399Gln with esophageal cancer risk in the Chinese population

Z. Y. Zhang, Xuan, Y., Jin, X. Y., Tian, X., and Wu, R., “Meta-analysis demonstrates association of XRCC1 genetic polymorphism Arg399Gln with esophageal cancer risk in the Chinese population”, vol. 12, pp. 2567-2577, 2013.

We made a meta-analysis of the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and esophageal cancer (EC) risk. Statistical analysis was performed with the Review Manager version 4.2.8 software program and STATA version 11.0. We selected 16 case-control studies for this meta-analysis, including 3591 EC cases and 5752 controls. Overall, the Gln399 allele was not associated with EC risk, compared with the Arg399 allele in the populations included in the analysis.

Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk

J. J. Hu, Wang, Z. T., and Li, B., “Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk”, vol. 12, pp. 4540-4548, 2013.

Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Tyr113His and His139Arg polymorphisms with esophageal cancer via a comprehensive meta-analysis. Publications before August 20, 2012 were included.

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