ERBB1

EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population

J. H. Torres-Jasso, Marín, M. E., Santiago-Luna, E., Leoner, J. C., Torres, J., Magaña-Torres, M. T., Perea, F. J., Ibarra, B., and Sánchez-López, J. Y., EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population, vol. 14, pp. 1802-1807, 2015.

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine-kinase activity that plays an important role in multiple cellular functions. EGFR overexpression has been observed in several types of tumors and it is significantly associated with disease stage, survival, prognosis, and progression of cancer. The polymorphisms -216G>T, -191C>A, and (CA)n first intervening sequence (IVS1) have been related to EGFR overexpression and have been studied in several types of cancer, but not in gastric cancer (GC).

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