ER22/23EK

Correlation between polymorphisms in the glucocorticoid receptor gene NR3C1 and susceptibility to asthma in a Chinese population from the Henan Province

Z. Cheng, Dai, L. L., Liu, Q., Liu, M., Wang, Q., Li, P. F., Wang, H., Jia, L. Q., An, L., Cheng, Z., Dai, L. L., Liu, Q., Liu, M., Wang, Q., Li, P. F., Wang, H., Jia, L. Q., and An, L., Correlation between polymorphisms in the glucocorticoid receptor gene NR3C1 and susceptibility to asthma in a Chinese population from the Henan Province, vol. 15, p. -, 2016.

The aim of this study was to investigate the association between four single nucleotide polymorphisms in NR3C1 (Tth111I, BclI, ER22/23EK, and N363S), which encode the glucocorticoid receptor, and asthma susceptibility in patients from the Henan Province of China. Three hundred and twenty-eight patients with asthma and 60 healthy volunteers were recruited to this study. The target SNPs were genotyped by polymerase chain reaction (PCR)-high resolution melting and PCR-restriction fragment length polymorphism.

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