Epithelial-mesenchymal transition

Snail-induced epithelial-mesenchymal transition in gastric carcinoma cells and generation of cancer stem cell characteristics

Y. J. Yang, Li, Z. B., Zhang, G. R., Wu, L. J., Yu, J. Y., Hu, L. J., Zhou, Y. L., Wang, H. D., Liang, D., Yang, Y. J., Li, Z. B., Zhang, G. R., Wu, L. J., Yu, J. Y., Hu, L. J., Zhou, Y. L., Wang, H. D., and Liang, D., Snail-induced epithelial-mesenchymal transition in gastric carcinoma cells and generation of cancer stem cell characteristics, vol. 15, p. -, 2016.

Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer stem cell characteristics of Snail-overexpressed cells. A pEGFP-C1-Snail eukaryotic expression plasmid was constructed and pEGFP-C1(-) and pEGFP-C1-Snail plasmids were extracted and transfected into SGC7901 cells using Lipofectamine 2000.

Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models

J. Y. Wang, Li, Z. H., Ye, M., Feng, Q., Chen, Z. M., Ye, X. S., Wu, Z. G., Wang, B., Liu, L., Yao, J., Wang, J. Y., Li, Z. H., Ye, M., Feng, Q., Chen, Z. M., Ye, X. S., Wu, Z. G., Wang, B., Liu, L., and Yao, J., Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models, vol. 15, p. -, 2016.

Biliary atresia (BA) is a destructive bile duct disease occurring in newborn children within a few weeks after birth. In this study, the effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition (EMT) in experimental BA was explored by constructing BA mouse models via Rhesus rotavirus vaccine infection. miR-29c and miR-129-5p expression was analyzed by real-time quantitative polymerase chain reaction. EMT was established by induction with transforming growth factor (TGF)-β1.

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