Epigenetics

Epigenetic mechanism of maternal post-traumatic stress disorder in delayed rat offspring development: dysregulation of methylation and gene expression

X. G. Zhang, Zhang, H., Liang, X. L., Liu, Q., Wang, H. Y., Cao, B., Cao, J., Liu, S., Long, Y. J., Xie, W. Y., Peng, D. Z., Zhang, X. G., Zhang, H., Liang, X. L., Liu, Q., Wang, H. Y., Cao, B., Cao, J., Liu, S., Long, Y. J., Xie, W. Y., and Peng, D. Z., Epigenetic mechanism of maternal post-traumatic stress disorder in delayed rat offspring development: dysregulation of methylation and gene expression, vol. 15, p. -, 2016.

Maternal post-traumatic stress disorder (PTSD) increases the risk of adverse neurodevelopmental outcomes in the child. Epigenetic alternations may play an essential role in the negative effects of PTSD. This study was aimed to investigate the possible epigenetic alterations of maternal PTSD, which underpins the developmental and behavioral impact. 24 pregnant Sprague-Dawley (SD) rats were randomly grouped into PTSD and control groups.

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