Enzyme specificity

Proteinase inhibition using small Bowman-Birk-type structures

J. H. Fernandez, Mello, M. O., Tanaka, A. S., Silva-Filho, M. C., Neshich, G., and Galgaro, L., Proteinase inhibition using small Bowman-Birk-type structures, vol. 6, pp. 846-858, 2007.

Bowman-Birk inhibitors (BBIs) are cysteine-rich and highly cross-linked small proteins that function as specific pseudosubstrates for digestive proteinases. They typically display a "double-headed" structure containing an independent proteinase-binding loop that can bind and inhibit trypsin, chymotrypsin and elastase.

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