Energy metabolism

Oligonucleotide microarray analysis reveals dysregulation of energy-related metabolism in insulin-sensitive tissues of type 2 diabetes patients

M. Wang, Wang, X. C., Zhao, L., Zhang, Y., Yao, L. L., Lin, Y., Peng, Y. D., and Hu, R. M., Oligonucleotide microarray analysis reveals dysregulation of energy-related metabolism in insulin-sensitive tissues of type 2 diabetes patients, vol. 13, pp. 4494-4504, 2014.

Impaired insulin action within skeletal muscle, adipose tissue, and the liver is an important characteristic of type 2 diabetes (T2D). In order to identify common underlying defects in insulin-sensitive tissues that may be involved in the pathogenesis of T2D, the gene expression profiles of skeletal muscle, visceral adipose tissue, and liver from autopsy donors with or without T2D were examined using oligonucleotide microarrays and quantitative reverse transcriptase-PCR.

A possible role of a cerebral energy gene in alcoholism

A. F. Ribeiro, Correia, D., Boerngen-Lacerda, R., and Brunialti-Godard, A. L., A possible role of a cerebral energy gene in alcoholism, vol. 11, pp. 404-411, 2012.

We examined a possible relationship between genes responsible for energy metabolism of the brain and addictive behavior in an animal model. We used non-inbred, Swiss mice exposed to a three-bottle free-choice model [water, 5% (v/v) ethanol, and 10% (v/v) ethanol] over a 16-week period, consisting of four phases: acquisition, withdrawal, reexposure, and quinine-adulteration.

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