Endothelial progenitor cells

Effects of the ginkgo biloba extract on the superoxide dismutase activity and apoptosis of endothelial progenitor cells from diabetic peripheral blood

M. Zhao, Wang, X. - X., and Wan, W. - H., Effects of the ginkgo biloba extract on the superoxide dismutase activity and apoptosis of endothelial progenitor cells from diabetic peripheral blood, vol. 13, pp. 220-227, 2014.

Although ginkgo biloba extract (GBE) was shown to have antioxidant effects, little has been reported on the ability to GBE to help endothelial progenitor cells (EPCs) resist oxidative stress. The present study evaluated the influence of different concentrations of GBE on superoxide dismutase (SOD) and apoptosis of diabetic peripheral blood EPCs. Twenty-five diabetic patients without any vascular complications were included in the experimental group, while 15 healthy adults made up the control group.

Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus

D. N. Fang, He, X. D., Li, X. H., Jia, H., Li, P. Y., Lu, Q., Quan, Z., and Wang, Q. L., Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus, vol. 13, pp. 1-10, 2014.

We investigated the effects of type 1 diabetes mellitus (T1DM) on endothelial progenitor cells (EPCs) at the molecular level and assessed the therapeutic potential of folic acid (FA) in DM. We downloaded the gene expression profile of the EPCs from T1DM patients before and after treatment with FA and from healthy controls. We identified the differentially expressed genes (DEGs) in the EPCs from T1DM patients before and after a four-week period of FA treatment and compared them with those obtained from the healthy subjects by using limma package in R language.

Association study of circulating endothelial progenitor cells and plasma prostacyclin levels in pulmonary hypertension rats

Y. Song, Association study of circulating endothelial progenitor cells and plasma prostacyclin levels in pulmonary hypertension rats, vol. 13, pp. 438-444, 2014.

The aim of this study was to investigate the correlation between circulating endothelial progenitor cell (EPC) levels and plasma prostacyclin (PGI2) concentrations in pulmonary hypertension (PH) rat models. Monocrotaline was used to induce PH, and the number of CD34/Flk-1-double-positive mononuclear cells in peripheral CD45-negative blood was counted by flow cytometry, which reflected EPC circulation. The Greiss method was used to detect the plasma PGI2 concentration. Simple linear regression analysis was used to analyze the relationship between EPC and PGI2.

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