Endometriosis

Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis

A. M. Barbosa, de Souza, S. R., Frare, A. B., Silva, R. C. Costa e, da Costa, I. R., Silva, K. S. Freitas e, Júnior, C. L. Ribeiro, Bordin, B. M., Moura, K. K. V. O., Barbosa, A. M., de Souza, S. R., Frare, A. B., Silva, R. C. Costa e, da Costa, I. R., Silva, K. S. Freitas e, Júnior, C. L. Ribeiro, Bordin, B. M., and Moura, K. K. V. O., Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis, vol. 15, p. -, 2016.

Endometriosis is a disease that affects 10 to 15% of the women of reproductive age. It is characterized by the presence of endometrial-like tissues outside of the uterus. Some definitions claim that the functional ectopic tissue is sensitive to the action of hormones. Severity of endometriosis is defined according to a system proposed by the American Society for Reproductive Medicine, which is based on laparoscopic findings.

Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis

R. Q. Yang, Teng, H., Xu, X. H., Liu, S. Y., Wang, Y. H., Guo, F. J., Liu, X. J., Yang, R. Q., Teng, H., Xu, X. H., Liu, S. Y., Wang, Y. H., Guo, F. J., and Liu, X. J., Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis, vol. 15, p. -, 2016.

We examined the aberrant microRNA (miRNA) expression profile responsible for the changes in angiogenesis observed in endometriotic lesions. This study revealed characteristic miRNA expression profiles associated with endometriosis in endometrial tissue and endometriotic lesions from the same patient, and their correlation with the most important angiogenic and fibrinolytic factors. miRNA expression was quantified using a microRNA array and reverse-transcription microRNA polymerase chain reaction.

Effects of conservative laparoscopic endometrial cystectomy and use of kidney-reinforcing and blood activating traditional Chinese medicine on ovarian functions

Y. H. Huang, Shen, L., Cai, A. H., and Liang, X. F., Effects of conservative laparoscopic endometrial cystectomy and use of kidney-reinforcing and blood activating traditional Chinese medicine on ovarian functions, vol. 14, pp. 645-650, 2015.

This study investigated functional changes in the ovaries of women who have had conservative laparoscopic endometrial cystectomy and the effects of traditional kidney-reinforcing and blood-activating Traditional Chinese Medicine (TCM) on ovarian function. Seventy female patients who underwent laparoscopic endometrial cystectomy were randomized into two groups: TCM group receiving kidney-reinforcing and blood-activating Chinese medicine (N = 35) and control group receiving only routine follow-up (N = 35).

TP53 gene polymorphisms at codons 11, 72, and 248 and association with endometriosis in a Brazilian population

C. M. Camargo-Kosugi, D’Amora, P., Kleine, J. P. F. O., Carvalho, C. V., Sato, H., Schor, E., and Silva, I. D. C. G., TP53 gene polymorphisms at codons 11, 72, and 248 and association with endometriosis in a Brazilian population, vol. 13, pp. 6503-6511, 2014.

We evaluated the association between TP53 gene polymorphisms and endometriosis in Brazilian women. Genomic DNA was extracted from swabs of buccal cells collected from hospital patients. TP53 gene polymorphisms were investigated at three codons: TP53*11 Glu/Gln or Lys (GAG->CAG or AAG), TP53*72 Arg/Pro (CCG->CCC), and TP53*248 Arg/Thr (CGG->TCG) using the polymerase chain reaction-restriction fragment length polymorphism method.

Association between the epidermal growth factor gene polymorphism and endometriosis in women from Brazil

C. B. N. Oliveira, Falagan-Lotsch, P., Souza, M. G., Santos, R. P., Encinas, F., Teles, H., Lasmar, R. B., Duarte, L. B., Granjeiro, J. M., and Penna, I. A., Association between the epidermal growth factor gene polymorphism and endometriosis in women from Brazil, vol. 13, pp. 7239-7245, 2014.

The aim of this study was to verify the association between the epidermal growth factor (EGF) +61 G/A polymorphism and the susceptibility to endometriosis using a case-control design study. The control group included fertile women without endometriosis and the case group included endometriosis patients. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to genotype the EGF +61 G/A polymorphism. Initially, a total of 184 individuals were analyzed.

Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women

M. P. Gallegos-Arreola, Figuera-Villanueva, L. E., Puebla-Pérez, A. M., Montoya-Fuentes, H., Suarez-Rincon, A. E., and Zúñiga-González, G. M., Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women, vol. 11, pp. 1401-1408, 2012.

The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 Mexican women with endometriosis. The observed genotype frequencies for controls and endometriosis patients were 8 and 22% for proline/proline (Pro/Pro), 30 and 34% for proline/arginine (Pro/Arg), and 62 and 44% for arginine/arginine (Arg/Arg), respectively.

Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies

Y. Z. Li, Wang, L. J., Li, X., Li, S. L., Wang, J. L., Wu, Z. H., Gong, L., and Zhang, X. D., Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies, vol. 12, pp. 1035-1044, 2013.

Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that VEGF plays a role in the progression of the disease, but individually published studies showed inconclusive results. We investigated the association between VEGF polymorphisms and the susceptibility to endometriosis.

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