E-cadherin

Association between the CDH1-472delA and -160C>A polymorphisms and diffuse and intestinal gastric cancer in a Mexican population

A. R. Bustos-Carpinteyro, Delgado-Figueroa, N., Santiago-Luna, E., Magaña-Torres, M. T., Sánchez-López, J. Y., Bustos-Carpinteyro, A. R., Delgado-Figueroa, N., Santiago-Luna, E., Magaña-Torres, M. T., and Sánchez-López, J. Y., Association between the CDH1-472delA and -160C>A polymorphisms and diffuse and intestinal gastric cancer in a Mexican population, vol. 15, p. -, 2016.

Gastric cancer (GC), the third leading cause of cancer-related deaths in Mexico and worldwide, can be classified into diffuse (DGC) or intestinal (IGC) types based on its histological characteristics. DGC is characterized by reduced expression of the cell adhesion protein E-cadherin, which is encoded by CDH1. The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results.

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