Doxorubicin

Effects of Shenkangling intervention on the MAPK pathway in rats with doxorubicin-induced nephropathy

S. Ai, Lin, Y. Y., Zheng, J., Qiu, C. X., Liu, Y. J., Lin, X., Ai, S., Lin, Y. Y., Zheng, J., Qiu, C. X., Liu, Y. J., and Lin, X., “Effects of Shenkangling intervention on the MAPK pathway in rats with doxorubicin-induced nephropathy”, vol. 15, p. -, 2016.

Shenkangling plays a role of Yishenhuoxue effect for the treatment of children with nephrotic syndrome. The aim of this study was to investigate the effects of Shenkangling intervention on the mitogen-activated protein kinase (MAPK) pathway in rats with Adriamycin-induced nephropathy (AN) and its underlying mechanism of action. Nephrosis was induced in healthy Sprague-Dawley rats by doxorubicin and the rats were untreated or treated with prednisone, simvastatin, Shenkangling, or a combination thereof.

Role of salubrinal in protecting cardiomyocytes from doxorubicin-induced apoptosis

N. Gong, Wu, J. H., Liang, Z. S., Jiang, W. H., and Wang, X. W., “Role of salubrinal in protecting cardiomyocytes from doxorubicin-induced apoptosis”, vol. 14, pp. 12377-12385, 2015.

We determined whether salubrinal can protect cardio­myocytes from doxorubicin-induced apoptosis and explored the related mechanisms to provide experimental evidence for exploring novel drug candidates to decrease cardiac toxicity. Neonatal rat cardiomyocytes were isolated, cultured in vitro, and pretreated with salubrinal (10, 20, or 40 μM) to observe their response to doxorubicin-induced cell apop­tosis.

Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells

S. F. Chen, Zhang, Z. Y., and Zhang, J. L., “Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells”, vol. 14, pp. 14548-14560, 2015.

It has been suggested that selected COX inhibitors can overcome multidrug resistance through the inhibition of ATP‑binding cassette-transporter proteins thereby enhancing the inhibitory effect of doxorubicin on human tumor growth and promoting the actions of cytostatics. However, their effect on lung cancer and the molecular mechanisms involved in the overcoming of multidrug resistance are unclear.

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