Down-regulation effect

Segment-specific targeting via RNA interference mediates down-regulation of OPN expression in hepatocellular carcinoma cells

F. Lin, Huang, C. M., Cao, J., Pei, Z. H., Gu, W. L., Fan, S. F., Li, K. P., and Lin, C. M., Segment-specific targeting via RNA interference mediates down-regulation of OPN expression in hepatocellular carcinoma cells, vol. 14, pp. 14440-14447, 2015.

Osteopontin (OPN) plays an important role in the metastasis and recurrence of tumors after resection of hepatocellular carcinoma (HCC). In this study, the down-regulation effect on OPN expression in HCC cells of RNA interference (RNAi) molecules designed to target different segments of OPN was investigated to identify a more effective site for OPN knockdown. Specific small interfering RNAs (siRNAs A, B, and C) of OPN were synthesized and transfected into an HCC cell line (HEP-G2; representing the OPNi-A, OPNi-B, and OPNi-C groups).

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