Double-stranded RNA (dsRNA)

Control of gene expression and genetic manipulation in the Trypanosomatidae

S. M. R. Teixeira and da Rocha, W. D., Control of gene expression and genetic manipulation in the Trypanosomatidae, vol. 2. pp. 148-158, 2003.

Mechanisms controlling gene expression in trypanosomatids depend on several layers of regulation, with most regulatory pathways acting at a post-transcriptional level. Consequently, these parasites can follow the rapid changes associated with transitions between the insect vector and the mammalian host, with instant reprogramming of genetic expression.

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