Structural evaluation of type 3 dopaminergic receptor gene (DRD3) in chronic anovulatory women
, “Structural evaluation of type 3 dopaminergic receptor gene (DRD3) in chronic anovulatory women”, vol. 7, pp. 140-151, 2008.
Dopamine receptor type 3 (DRD3) expressed in the limbic system sites involved in the regulation of GnRH seems to play a role in neuroendocrine control. We hypothesized that women with chronic anovulation should show exacerbated secretion of prolactin (PRL) after thyrotropin-releasing hormone (TRH) stimulation test, having more chances for dopamine inhibitory dysfunction due to alterations in the structure of DRD3. The DRD3-coding region was evaluated in 60 women with chronic anovulation (35 without and 25 with hyperresponse of PRL after TRH stimulation), and in 34 controls.
