Dopamine

Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese

Y. Zhao, Ding, M., Pang, H., Xu, X. M., and Wang, B. J., “Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese”, vol. 13, pp. 1609-1618, 2014.

Dopamine (DA) has been implicated in the pathophysiol­ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa­mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect gene expression, influence biosynthesis of DA and underlie various neuropsychiatric disorders re­lated to DA dysfunction.

Structural evaluation of type 3 dopaminergic receptor gene (DRD3) in chronic anovulatory women

A. D. S. Santos, Prado, R. A. A., Melo, M. B., Melo, M. R., and Longui, C. A., “Structural evaluation of type 3 dopaminergic receptor gene (DRD3) in chronic anovulatory women”, vol. 7, pp. 140-151, 2008.

Dopamine receptor type 3 (DRD3) expressed in the limbic system sites involved in the regulation of GnRH seems to play a role in neuroendocrine control. We hypothesized that women with chronic anovulation should show exacerbated secretion of prolactin (PRL) after thyrotropin-releasing hormone (TRH) stimulation test, having more chances for dopamine inhibitory dysfunction due to alterations in the structure of DRD3. The DRD3-coding region was evaluated in 60 women with chronic anovulation (35 without and 25 with hyperresponse of PRL after TRH stimulation), and in 34 controls.

Genetic, biochemical, and anatomic characterization of neurological mutant 3, a new mouse model for Parkinson’s disease

M. E. Legare and Hanneman, W. H., “Genetic, biochemical, and anatomic characterization of neurological mutant 3, a new mouse model for Parkinson’s disease”, vol. 2, pp. 288-294, 2003.

We have identified a new mutant mouse that we have named new mouse neurological mutant 3 (NM3); it may be a useful model to understand the underlying molecular and genetic basis of Parkinson’s disease (PD). A mouse carrying the NM3 mutation arose spontaneously in an RIIIS/J breeding colony and was identified as having a movement disorder. Upon neurological examination of these mice, their movement was found to be slow and abnormal, with characteristic choreaform and bradykinetic-type movements, typical of PD.

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