DNMT

Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China

M. - Y. Sun, Yang, X. - X., Xu, W. - W., Yao, G. - Y., Pan, H. - Z., and Li, M., Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China, vol. 11, pp. 4330-4341, 2012.

Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide polymorphisms (SNPs) in DNMT1, DNMT3A, DNMT3B, DNMT3L, and DNMT2 with breast cancer among Han Chinese women from South China.

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