DNA damage

Cytogenetic findings in patients diagnosed with breast cancer having undergone adjuvant chemotherapy regimens

P. A. Koşar, Koçer, M., Çelik, D. A., Ozcelik, N., Koşar, P. A., Koçer, M., Çelik, D. A., Ozcelik, N., Koşar, P. A., Koçer, M., Çelik, D. A., and Ozcelik, N., Cytogenetic findings in patients diagnosed with breast cancer having undergone adjuvant chemotherapy regimens, vol. 15, p. -, 2016.

The aim of the present study was to investigate DNA damage in peripheral blood lymphocytes of breast cancer (BC) patients before and after administration of chemotherapy. We analyzed the frequency of sister chromatid exchange (SCE), occurrence of micronuclei (MN), and lymphocyte proliferation rate index (PRI) as cytogenetic markers in 28 female BC patients before and after chemotherapy, and in 20 age-matched healthy female volunteers. Prior to treatment, BC patients showed significantly increased background levels of SCE and MN, and lowered PRIs compared to healthy women.

Correlation between sperm ultrastructure in infertile patients with abnormal sperm morphology and DNA damage

M. He and Tan, L., Correlation between sperm ultrastructure in infertile patients with abnormal sperm morphology and DNA damage, vol. 14, pp. 17000-17006, 2015.

This study explored the correlation between sperm ultrastructure in infertile patients with abnormal sperm morphology and DNA damage. Three unusual sperm morphologies were selected for the experimental group namely case 1 (95% headless sperm), case 2 (98% headless sperm), and case 3 (100% headless sperm), and the control group consisted of 2 subjects (20 and 15% headless sperm). For case 1, the patient was negative for sexually transmitted diseases and had normal semen plasma biochemistry, reproductive hormones, peripheral blood chromosomes, and azoospermia factor (AZF).

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