Disease progression

3'-UTR polymorphism (rs10434) in the VEGF gene is associated with B-CLL in a Chinese population

L. X. Zhu, Ye, X. J., Wang, Y. G., Zhu, J. J., Xie, W. Z., Zhao, Y. M., and Lai, X. Y., 3'-UTR polymorphism (rs10434) in the VEGF gene is associated with B-CLL in a Chinese population, vol. 14, pp. 4085-4089, 2015.

We investigated the relationship between a VEGF genetic polymorphism and B cell chronic lymphocytic leukemia (B-CLL). A total of 102 patients with B-CLL and 124 healthy subjects were included in this study. All individuals were typed for the rs10434 in the vascular endothelial growth factor (VEGF) gene using the TaqMan technique. We found that the A allele and the AA genotype of rs10434 were more frequent in B-CLL patients than in control subjects (0.54 vs 0.34; 27 vs 13%; respectively).

Gene expression profiling of Duchenne muscular dystrophy reveals characteristics along disease progression

L. J. Tian, Cao, J. H., Deng, X. Q., Zhang, C. L., Qian, T., Song, X. X., and Huang, B. S., Gene expression profiling of Duchenne muscular dystrophy reveals characteristics along disease progression, vol. 13, pp. 1402-1411, 2014.

Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy with no cure currently available. In this study, using two microarray data sets obtained from the Gene Expression Omnibus database, we conducted a dysfunctional pathway-enrichment analysis and investigated deregulated genes that are specific to different phases of the disease in order to determine pathogenic characteristics in the progression of DMD.

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