Direct genotyping

Application of indirect linkage analysis and direct genotyping to hemophilia A carrier detection in Sichuan, China

P. Sun, Ma, L., Diao, G., Li, C. Q., and Lin, F. Z., Application of indirect linkage analysis and direct genotyping to hemophilia A carrier detection in Sichuan, China, vol. 14, pp. 8229-8235, 2015.

Hemophilia A (HA) is an inherited X-linked bleeding disorder caused by mutations in the factor VIII gene. Prenatal detec­tion in female carriers from families with HA is important to reduce the number of HA patients. The purpose of this study was to detect carriers in families with HA from Sichuan, China, using linkage analysis and a direct genotyping method. A total of 18 HA families were studied.

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