Dimorphism

The cell wall of Paracoccidioides brasiliensis: insights from its transcriptome

P. Kott Tomazett, Cruz, A. Helena da, Bonfim, S. Maria Rond, Soares, C. Maria de A., and Pereira, M., The cell wall of Paracoccidioides brasiliensis: insights from its transcriptome, vol. 4, pp. 309-325, 2005.

The cell wall of a human pathogenic fungus is in contact with the host, serves as a barrier against host defense mechanisms and harbors most fungal antigens. In addition, cell wall biosynthesis pathways have been recognized as essential to viability and as specific drug targets. Paracoccidioides brasiliensis is a dimorphic fungus that presents mycelium morphology in the free environment and causes infection in a yeast form. The morphogenetic conversion is correlated with changes in the cell wall composition, organization and structure.

Virulence insights from the Paracoccidioides brasiliensis transcriptome

A. Henrique Tavares, Silva, S. Souza, Bernardes, V. Vilmar, Maranhão, A. Queiróz, Maranhão, A. Queiróz, Kyaw, C. Maria Kyaw, Poças-Fonseca, M., and Silva-Pereira, I., Virulence insights from the Paracoccidioides brasiliensis transcriptome, vol. 4. pp. 372-389, 2005.

Paracoccidioides brasiliensis, the etiologic agent of paracoccidioidomycosis, is a dimorphic fungus, which is found as mycelia at 22-26ºC and as yeasts at 37ºC. A remarkable feature common to several pathogenic fungi is their ability to differentiate from mycelium to yeast morphologies, or vice-versa. Although P. brasiliensis is a recognized pathogen for humans, little is known about its virulence genes. In this sense, we performed a search for putative virulence genes in the P. brasiliensis transcriptome.

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