Dimorphic fungus

General metabolism of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis

F. B. M. Arraes, Benoliel, B., Burtet, R. T., Costa, P. L. N., Galdino, A. S., Lima, L. H. A., Marinho-Silva, C., Oliveira-Pereira, L., Pfrimer, P., Procópio-Silva, L., Reis, V. Castelo- Br, and Felipe, M. Sueli S., General metabolism of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis, vol. 4, pp. 290-308, 2005.

Annotation of the transcriptome of the dimorphic fungus Paracoccidioides brasiliensis has set the grounds for a global understanding of its metabolism in both mycelium and yeast forms. This fungus is able to use the main carbohydrate sources, including starch, and it can store reduced carbons in the form of glycogen and trehalose; these provide energy reserves that are relevant for metabolic adaptation, protection against stress and infectivity mechanisms. The glyoxylate cycle, which is also involved in pathogenicity, is present in this fungus.

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