Dilated cardiomyopathy

Association of the LMNA gene single nucleotide polymorphism rs4641 with bdilated cardiomyopathy

J. Yin, Yang, J., Ren, F. X., Sun, C. M., Li, L. D., Han, L. Y., Cai, S. L., Zhang, C. H., Zhang, Z. Q., Zhang, Z. T., and Wang, H., “Association of the LMNA gene single nucleotide polymorphism rs4641 with bdilated cardiomyopathy”, vol. 14, pp. 15427-15434, 2015.

Recently, studies on the pathogenesis of dilated cardiomyopathy (DCM) have focused on the underlying molecular biology and the association between single nucleotide polymorphisms (SNPs) and disease. This study was designed to explore the association between the rs4641 SNP of the LMNA gene and DCM in order to identify a new gene locus related to DCM. Polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing were employed to detect and genotype rs4641 in 198 patients with DCM and 160 healthy controls.

Significance of sarcomere gene mutation in patients with dilated cardiomyopathy

Y. D. Li, Ji, Y. T., Zhou, X. H., Li, H. L., Zhang, H. T., Zhang, Y., Li, J. X., Xing, Q., Zhang, J. H., Hong, Y. F., and Tang, B. P., “Significance of sarcomere gene mutation in patients with dilated cardiomyopathy”, vol. 14, pp. 11200-11210, 2015.

Dilated cardiomyopathy (DCM) is a myocardial disease with a high mortality rate. Approximately 40 genes have been found to be associated with DCM to date. Non-familial DCM can also be caused by gene mutations, suggesting that genetic factors were involved in the pathogenesis of DCM; therefore genetic testing is beneficial for the early diagnosis of DCM, which can facilitate the implementation of preventive measures by and within patient’s families. Here, we investigated the underlying genetic mutations involved in the cause of patients with DCM.

Subscribe to Dilated cardiomyopathy