Diabetes

Distinct non-cerebrovascular risk factors for ischemic lacunar stroke and non-lacunar stroke: preliminary results

Y. F. Chen, Luo, C. H., Liu, Y. J., Lu, W. H., and Su, B. R., Distinct non-cerebrovascular risk factors for ischemic lacunar stroke and non-lacunar stroke: preliminary results, vol. 14, pp. 3170-3176, 2015.

Stroke is a non-communicable disease of increasing socioeconomic importance in aging populations. This study compared the risk factors implicated in two subtypes of ischemic stroke: lacunar stroke (LS) and non-lacunar stroke (NLS). A retrospective case control study was conducted on a total of 368 patients [220 cases (59.8%) of NLS and 148 cases (40.2%) of LS] with first-time onset of ischemic stroke. Multivariate logistic regression was performed to compare multiple non-cerebrovascular risk factors between the two groups.

Observed impacts of insulin therapy on callus cell transforming growth factor-beta 1 expression in diabetic rats

L. X. Wang, Jiang, H. L., and Du, S. L., Observed impacts of insulin therapy on callus cell transforming growth factor-beta 1 expression in diabetic rats, vol. 14, pp. 5076-5084, 2015.

The expression of transforming growth factor-beta 1 (TGF-β1) inside the callus cells of diabetic rats and the impact of insulin therapy on its expression and biomechanics was investigated. The rats were randomly divided as follows: an insulin therapy group (IT), a diabetic model group (DM), and a non-diabetic control group (NC). Bone specimens from each group were extracted at different times for immunohistochemical observation of the expression of TGF-β1. Concurrently, the destruction torque and torsional stiffness were detected at different times.

Association of neural tube defects in children of mothers with MTHFR 677TT genotype and abnormal carbohydrate metabolism risk: a case-control study

N. M. Cadenas-Benitez, Yanes-Sosa, F., Gonzalez-Meneses, A., Cerrillos, L., Acosta, D., Praena-Fernandez, J. M., Neth, O., I. de Terreros, G., and Ybot-González, P., Association of neural tube defects in children of mothers with MTHFR 677TT genotype and abnormal carbohydrate metabolism risk: a case-control study, vol. 13, pp. 2200-2207, 2014.

Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTD) in humans and animal models. However, the relationship between these two factors in the development of NTDs remains unclear. Data from mothers of children with spina bifida seen at the Unidad de Espina Bífida del Hospital Infantil Virgen del Rocío (case group) were compared to mothers of healthy children with no NTD (control group) who were randomly selected from patients seen at the outpatient ward in the same hospital.

Association of serum adipose triglyceride lipase levels with obesity and diabetes

L. Yang, Chen, S. J., Yuan, G. Y., Zhou, L. B., Wang, D., Wang, X. Z., and Chen, J. J., Association of serum adipose triglyceride lipase levels with obesity and diabetes, vol. 13, pp. 6746-6751, 2014.

The aim of this study was to detect the serum adipose triglyceride lipase (ATGL) levels in obesity and newly diagnosed type 2 diabetes patients, and to explore the association between ATGL with glucose and lipid metabolism. We enrolled 66 patients with type 2 diabetes and 48 patients with normal glucose regulation, who were divided into an overweight or obese subgroup and a normal weight subgroup according to body mass index (BMI) ≥ 25 kg/m2. The enzyme-linked immunosorbent assay was used to detect fasting blood glucose, blood lipids, fasting insulin, and ATGL levels.

Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians

J. Liu, Zhang, H. X., Feng, G. Y., and He, L., Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians, vol. 12, pp. 3919-3930, 2013.

We evaluated association of polymorphisms in the CTLA-4 gene with the risk of type 1 diabetes mellitus. Comprehensive meta-analysis was applied to case-control studies of the association between CTLA-4 and type 1 diabetes mellitus to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We searched PubMed, Medline, Embase, Cochrane Library, and reference lists of relevant studies to February 2012, and made email contact with authors.

Prevalence of diabetes and impaired fasting glucose in Uygur children of Xinjiang, China

J. Zhang, Ma, Y. T., Xie, X., Yang, Y. N., Liu, F., Li, X. M., Fu, Z. Y., Ma, X., Chen, B. D., Zheng, Y. Y., Yu, Z. X., and Chen, Y., Prevalence of diabetes and impaired fasting glucose in Uygur children of Xinjiang, China, vol. 12, pp. 5007-5012, 2013.

This study was designed to estimate the prevalence of diabetes and impaired fasting glucose (IFG) in Xinjiang children in western China. Data were obtained from the Chun-Miao Project, a community-based, cross-sectional study designed to investigate the prevalence and risk factors of diabetes in children of the Chinese Uygur population in Xinjiang from February 2010 to May 2012. A total of 3644 children completed the survey and measurements of fasting glucose. Diabetes and IFG were defined using American Diabetes Association 2009 criteria.

Association between the Rs3087243 polymorphism and risk for diabetes: a meta-analysis

J. Liu and Zhang, H. - X., Association between the Rs3087243 polymorphism and risk for diabetes: a meta-analysis, vol. 12, pp. 6344-6350, 2013.

The aim of this study was to evaluate the association between the rs3087243 polymorphism of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene and the risk of type 1 diabetes mellitus (T1D). A comprehensive meta-analysis of case-control studies was conducted to determine the association between the rs3087243 polymorphism (CT60A/G) and T1D and assess the joint evidence for the abovementioned association, influence of individual studies, and evidence for publication bias.

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