Developmentally regulated amplified segment

Molecular combing in the analysis of developmentally regulated amplified segments of Bradysia hygida

K. J. R. Passos, Togoro, S. Y., Carignon, S., Koundrioukoff, S., Lachages, A. - M., Debatisse, M., and Fernandez, M. A., Molecular combing in the analysis of developmentally regulated amplified segments of Bradysia hygida, vol. 11, pp. 2060-2070, 2012.

Molecular combing technology is an important new tool for the functional and physical mapping of genome segments. It is designed to identify amplifications, microdeletions, and rearrangements in a DNA sequence and to study the process of DNA replication. This technique has recently been used to identify and analyze the dynamics of replication in amplified domains. In Bradysia hygida, multiple amplification initiation sites are predicted to exist upstream of the BhC4-1 gene. However, it has been impossible to identify them using the available standard techniques.

Subscribe to Developmentally regulated amplified segment