Der p 1

Effect of the house dust mite allergen Der p 1 on tryptase release from human mast cells

D. Q. Wang, Shen, Y. Y., Xu, J. H., Tang, H., Wang, D. Q., Shen, Y. Y., Xu, J. H., and Tang, H., Effect of the house dust mite allergen Der p 1 on tryptase release from human mast cells, vol. 15, p. -, 2016.

This study aimed to investigate the effects of the house dust mite allergen Der p 1 on the secretion of tryptase from the human mast cell line HMC-1. Flow cytometry was used to determine the expression levels of protease-activated receptor-2 (PAR2) on the surface of HMC-1 cells. HMC-1 cells were treated with Der p 1, SLIGRL-NH2 (PAR2 agonist), LRGILS-NH2 (control peptide for PAR2), or Der p 1 + FSLLRY (PAR2 antagonist), and the tryptase levels were measured using enzyme-linked immunosorbent assay.

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