Dehydroepiandrosterone

Effect of dehydroepiandrosterone treatment on hormone levels and antioxidant parameters in aged rats

F. J. Yin, Kang, J., Han, N. N., and Ma, H. T., Effect of dehydroepiandrosterone treatment on hormone levels and antioxidant parameters in aged rats, vol. 14, pp. 11300-11311, 2015.

The aim of the current study was to evaluate the effect of chronic dehydroepiandrosterone (DHEA) administration on steroid hormones and antioxidant parameters in aged rats. To this end, three groups of Sprague-Dawley rats were compared: young (3 months of age) untreated; aged (19 months old) untreated; and aged rats treated with 20 mg/kg DHEA for 8 weeks. Major organs of aged rats in the untreated group demonstrated physiological atrophy, compared to those of young rats; this effect appeared to have been partially reversed by DHEA treatment.

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