Cytoskeleton

Cytoskeleton changes of airway smooth muscle cells in juvenile rats with airway remodeling in asthma and the RhoA/ROCK signaling pathway mechanism

B. Wei, Shang, Y. X., Li, M., Jiang, J., and Zhang, H., Cytoskeleton changes of airway smooth muscle cells in juvenile rats with airway remodeling in asthma and the RhoA/ROCK signaling pathway mechanism, vol. 13, pp. 559-569, 2014.

This article aimed to investigate changes in the cytoskeleton of airway smooth muscle cells (ASMCs) in juvenile rats with airway remodeling in asthma. We further investigated the involvement of the RhoA/ROCK signaling pathway mechanism. Rat models of airway remodeling in asthma were established by antigen sensitization with ovalbumin for 2, 4, 6, and 8 weeks. The control group was treated with normal saline instead of ovalbumin. In the intervention group, after 8 weeks of culture, ASMCs were treated with the ROCK-specific inhibitor Y-27632.

New roles of filopodia and podosomes in the differentiation and fusion process of osteoclasts

R. L. Song, Liu, X. Z., Zhu, J. Q., Zhang, J. M., Gao, Q., Zhao, H. Y., Sheng, A. Z., Yuan, Y., Gu, J. H., Zou, H., Wang, Q. C., and Liu, Z. P., New roles of filopodia and podosomes in the differentiation and fusion process of osteoclasts, vol. 13, pp. 4776-4787, 2014.

The cytoskeleton mediates various cellular processes such as differentiation and fusion, including in the filopodia and podosomes. However, apart from cell migration and formation of the sealing zone, little is known regarding the changes and related regulatory mechanisms of the cytoskeleton and additional roles of the filopodia and podosomes during the differentiation and fusion of osteoclasts. The cytomorphology and cytoskeleton of osteoclasts in the differentiation process were evaluated using tartrate-resistant acid phosphatase staining and immunofluorescence staining.

Subscribe to Cytoskeleton