Cytochalasin B

Cytochalasin B inhibits the proliferation of human glioma U251 cells through cell cycle arrest and apoptosis

Z. G. Tong, Liu, N., Song, H. S., Li, J. Q., Jiang, J., Zhu, J. Y., and Qi, J. P., Cytochalasin B inhibits the proliferation of human glioma U251 cells through cell cycle arrest and apoptosis, vol. 13, pp. 10811-10822, 2014.

Cytochalasin B (CB) is known to inhibit a number of cancer types, but its effects on gliomas are unknown. We examined the in vitro effects of CB on the proliferation of human glioma U251 cells, as well as determined its mechanism of action. Cell proliferation was determined using CCK-8. The effect of CB on U251 cell morphology was observed under a transmission electron microscope. Cell cycle distribution was assessed using propidium iodine and Giemsa staining, and cell apoptosis was determined by annexin V-fluorescein isothiocyanate/propidium iodide.

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