Crohn’s disease

Correlation between IRGM genetic polymorphisms and Crohn’s disease risk: a meta-analysis of case-control studies

Y. Li, Feng, S. - T., Yao, Y., Yang, L., Xing, Y., Wang, Y., and You, J. - H., Correlation between IRGM genetic polymorphisms and Crohn’s disease risk: a meta-analysis of case-control studies, vol. 13, pp. 10741-10753, 2014.

This meta-analysis was performed to evaluate the relationships between single-nucleotide polymorphisms (SNPs) in the immunity-related GTPase M (IRGM) gene and the risk of Crohn’s disease (CD). Eleven case-control studies were included, for a total of 5183 CD patients and 5571 healthy controls. Three common SNPs (rs13361189 C>T, rs10065172 C>T, and rs4958847 A>G) in the IRGM gene were assessed.

Co-inheritance of variants/mutations in Malaysian patients with Crohn’s disease

K. H. Chua, Ng, C. C., Hilmi, I., and Goh, K. L., Co-inheritance of variants/mutations in Malaysian patients with Crohn’s disease, vol. 11, pp. 3115-3121, 2012.

Crohn’s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohn’s disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms that could influence Crohn’s disease development. Based on the sequencing results, a homozygous 5ꞌ-UTR-59 G to A variant in exon 1 (SNP6) was observed in a patient who carried SNP5, while a heterozygous SNP6 variant was detected in the other patient who carried SNP5.

Lack of association between TYK2 and STAT3 genes and Crohn’s disease in the Malaysian population

L. H. Lian, Lau, T. P., Lee, V. L., Lee, W. S., Hilmi, I., Goh, K. L., and Chua, K. H., Lack of association between TYK2 and STAT3 genes and Crohn’s disease in the Malaysian population, vol. 12, pp. 167-174, 2013.

This study aimed to investigate the potential association of TYK2 and STAT3 genes with the susceptibility to Crohn’s disease (CD) among Malaysians. DNA samples were obtained from 80 CD patients and 100 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism methods were employed for genotyping, followed by statistical analysis. In our current study, none of the single nucleotide polymorphisms of either TYK2 or STAT3 was statistically associated with the susceptibility to CD in our local population (P > 0.05).

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