cortisol

Non-invasive determination of the immune physiological state of reindeer (Rangifer tarandus) in the Greater Khingan Mountains, China

Y. J. Yin, Nie, C. Y., Liu, W. S., Zou, Q., Zhai, J. C., Han, H. S., and Li, H. P., “Non-invasive determination of the immune physiological state of reindeer (Rangifer tarandus) in the Greater Khingan Mountains, China”, vol. 14, pp. 6664-6673, 2015.

Immunoglobulin and cortisol levels are good indicators of well-being and living status in animals. In this study, the concentrations of fecal immunoglobulins A ([IgAF]), G ([IgGF]), and M ([IgMF]), and cortisol ([cortisolF]) were examined by enzyme-linked immunosorbent assay in reindeer of the Greater Khingan Mountains of Inner Mongolia, China.

Persistent glucocorticoid resistance in systemic lupus erythematosus patients during clinical remission

A. K. G. Melo, Melo, M. R., Saramago, A. B. A., Demartino, G., Souza, B. D. B., and Longui, C. A., “Persistent glucocorticoid resistance in systemic lupus erythematosus patients during clinical remission”, vol. 12, pp. 2010-2019, 2013.

Glucocorticoids (GCs) are key drugs in the treatment of systemic lupus erythematosus (SLE). GC dose reduction during remission is related to disease activity, GC dose used, length of treatment, and individual GC sensitivity. We compared GC receptor α (GRα) isoform and nuclear factor kappaB (NF-κB) messenger RNA quantitation and in vivo GC sensitivity between SLE patients during remission and healthy controls. We performed a cross-sectional study of 19 women aged 22-49 years, including 9 SLE patients in clinical remission taking ≤5 mg prednisone and 10 matched controls.

Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles

T. Nakamura, Okamura, N., Yagi, M., Omatsu, H., Yamamori, M., Kuwahara, A., Nishiguchi, K., Horinouchi, M., Okumura, K., and Sakaeda, T., “Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles”, vol. 8, pp. 397-403, 2009.

ABCB1, also known as MDR1/P-glycoprotein, can transport cortisol and aldosterone. We examined the effects of ABCB1 polymorphisms on serum levels of cortisol and aldosterone among different phases of the normal menstrual cycle in 51 non-pregnant healthy Japanese female volunteers (22 ± 1 years old). The menstrual cycle was divided into three phases: premenstrual phase (14 days preceding the onset of menstruation, N = 22; menstrual phase, N = 11, and postmenstrual phase, N = 18). ABCB1 -129T>C, 1236C>T, 2677G>A/T, and 3435C>T genotypes were determined.

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