Coronary heart disease

Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population

J. D. Sun, Yuan, H., Hu, H. Q., Yu, H. M., Sun, J. D., Yuan, H., Hu, H. Q., and Yu, H. M., “Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population”, vol. 15, p. -, 2016.

We investigated the possible correlations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of coronary heart disease (CHD). CHD patients (113) and healthy controls (118) were enrolled from the First People’s Hospital of Yuhang between January 2013 and June 2014. The patients were divided into mild CHD (N = 72) and severe CHD (N = 41) subgroups. DNA samples were extracted and the distributions of NAT2 polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease

Y. Y. Chen, Wang, B. N., Yu, X. P., Chen, Y. Y., Wang, B. N., Yu, X. P., Chen, Y. Y., Wang, B. N., and Yu, X. P., “Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease”, vol. 15, p. -, 2016.

The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An additional 200 healthy volunteers were enrolled as the control group. Serum HCY levels, MTHFR C677T genotype, and other related indicators were evaluated for the two groups.

Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease

J. Y. Zhong, Zheng, X. W., Ye, H. D., Cui, H. B., Du, W. P., Zhang, Z. X., Fei, X. H., Lin, S. Y., Wang, J., Su, J., Chen, X. M., and Duan, S. W., “Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease”, vol. 14, pp. 11745-11751, 2015.

APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls were tested in the current association study.

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

C. M. Wang, Ye, H. D., Li, Y. R., Hong, Q. X., Tang, L. L., Zhou, A. N., Xu, M. Q., and Duan, S. W., “Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population”, vol. 14, pp. 12254-12261, 2015.

Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case-control study was involved with 1509 unrelated individuals, including 777 CHD cases and 732 controls.

Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men

Y. Huang, Ye, H. D., Gao, X., Nie, S., Hong, Q. X., Ji, H. H., Sun, J., Zhou, S. J., Fei, B., Li, K. Q., Zhao, J. K., Wang, Z. P., Xu, M. Q., and Duan, S. W., “Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men”, vol. 14, pp. 13414-13424, 2015.

Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution of rs4420638 to the risk of CHD in Han Chinese. In addition, we performed a meta-analysis to evaluate the association between rs4420638 and CHD in Europeans and Asians.

APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease

Y. Sun, Zhou, R. B., and Chen, D. M., “APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease”, vol. 14, pp. 18218-18228, 2015.

The aim of this study was to investigate correlations between apolipoprotein A-V (APOA5) -1131T>C and apolipoprotein C-III (APOC3) -455T>C polymorphisms and coronary heart disease (CHD). PubMed, Ovid, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched using combinations of keywords relating to these polymorphisms and CHD.

Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity

H. L. Zhang and Jin, X., “Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity”, vol. 14, pp. 11023-11029, 2015.

This study aimed to explore serum adiponectin and osteoprotegerin levels in patients with coronary heart disease (CHD) and their correlation with inflammatory and ischemia factors. From September 2010 to Augest 2010, 347 CHD patients were enrolled for a retrospective analysis. Serum lipoprotein phospholipase A2 (Lp-PLA2), hypersensitive C-reactive protein (hs-CRP), ischemia modified albumin (IMA), and adiponectin and osteoprotegerin levels were detected and analyzed.

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