Coronary artery disease

Association between interleukin 17A gene polymorphisms and risk of coronary artery disease

X. S. Zheng, Wang, S., Ni, M., Zheng, X. S., Wang, S., and Ni, M., Association between interleukin 17A gene polymorphisms and risk of coronary artery disease, vol. 15, p. -, 2016.

Coronary artery disease (CAD) represents a leading cause of morbidity and mortality worldwide, and genetic factors contribute to the development of this disease. We conducted a case-control study to assess the association between interleukin 17A (IL17A) rs2275913 and rs3748067 polymorphisms and development of CAD. A total of 372 CAD patients and 372 healthy controls were recruited in our investigation between January 2013 and December 2014.

APOA5 -1131T/C polymorphism and coronary artery disease susceptibility in Chinese population: an updated meta-analysis

J. Zhang, Wan, D. G., Song, H. L., and Zhang, W. G., APOA5 -1131T/C polymorphism and coronary artery disease susceptibility in Chinese population: an updated meta-analysis, vol. 14. pp. 12330-12339, 2015.

Although many studies have investigated the association of the APOA5 -1131T/C polymorphism with coronary artery disease (CAD), definite conclusions have not been drawn. To understand the effects of the APOA5 -1131T/C polymorphism on the risk of developing CAD, we performed an updated meta-analysis in the Chinese population. Relevant studies published till April 2015 were identified from databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine.

Association of interleukin gene polymorphisms with the risk of coronary artery disease

H. T. Yang, Wang, S. L., Yan, L. J., Qian, P., and Duan, H. Y., Association of interleukin gene polymorphisms with the risk of coronary artery disease, vol. 14, pp. 12489-12496, 2015.

We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD). A total of 410 individuals with CAD were enrolled between January 2012 and December 2014.

ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk

N. Jiang, Yang, G., and Peng, C. L., ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk, vol. 14, pp. 13932-13944, 2015.

The aim of this meta-analysis was to evaluate the correlations between the estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scientific literature databases, which was complemented by manual searches. Data from studies selected were analyzed using the Comprehensive Meta-analysis 2.0 software.

Role of interleukin-10 gene polymorphisms in the development of coronary artery disease in Chinese population

H. M. Xu and Liu, Y. R., Role of interleukin-10 gene polymorphisms in the development of coronary artery disease in Chinese population, vol. 14, pp. 15869-15875, 2015.

The aim of this study was to investigate the association between three common SNPs (-1082A/G, -819T/C, and -592A/C) in the interleukin 10 (IL-10) gene, and the development of coronary artery disease. Between January 2013 and December 2014, 272 patients with coronary artery disease and control subjects (each) were recruited for this study from the Huaihe Hospital of Henan University. The IL-10-1082A/G, -819T/C and -592A/C gene polymorphisms were analyzed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.

Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases

Y. Li, Zhu, J., and Ding, J. Q., Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases, vol. 14, pp. 18662-18674, 2015.

This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of high-quality patients-control studies.

Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis

L. L. Zhang, Wang, Y. Q., Fu, B., Zhao, S. L., and Kui, Y., Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis, vol. 14, pp. 18503-18514, 2015.

We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and 5016 controls in 12 case-control studies were included in this meta-analysis.

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