Coronary artery disease

Association between NOS3 genetic variants and coronary artery disease in the Han population

G. L. Zhao, Li, Q. J., Lu, H. Y., Zhao, G. L., Li, Q. J., and Lu, H. Y., Association between NOS3 genetic variants and coronary artery disease in the Han population, vol. 15, p. -, 2016.

The enzyme endothelial nitric oxide synthase (NOS3) is an important mediator of atherosclerotic disease and is associated with coronary artery disease (CAD). There is growing evidence that polymorphisms in NOS3 influence the progression of CAD; however, there is also a controversy regarding the association of polymorphisms in the gene encoding NOS3 and CAD.

Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population

L. Mao, Geng, G. Y., Han, W. J., Zhao, M. H., Wu, L., Liu, H. L., Mao, L., Geng, G. Y., Han, W. J., Zhao, M. H., Wu, L., and Liu, H. L., Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population, vol. 15, p. -, 2016.

To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction fragment length polymorphism. Results indicated that several disease risk factors were significantly higher in CAD patients as compared to the control subjects.

Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population

K. Liang, Dong, S. R., Peng, H., Liang, K., Dong, S. R., Peng, H., Liang, K., Dong, S. R., and Peng, H., Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and December 2014. Subjects were genotyped for IL-10-G1082A polymorphisms by using polymerase chain reaction-restriction fragment length polymorphism.

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