Copy number variation

CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription

Z. Su, Liu, G., Song, X., Liang, B., Chang, X., Huang, D., Su, Z., Liu, G., Song, X., Liang, B., Chang, X., and Huang, D., CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription, vol. 15, p. -, 2016.

The dehydrogenase/reductase (SDR family) member 4 (DHRS4) gene is copied during mammalian evolution; therefore, while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively.

Molecular cloning, tissue expression pattern, and copy number variation of porcine SCUBE3

X. Liu, Wang, L. G., Zhang, L. C., Yan, H., Zhao, K. B., Liang, J., Li, N., Pu, L., Zhang, T., Wang, L. X., Liu, X., Wang, L. G., Zhang, L. C., Yan, H., Zhao, K. B., Liang, J., Li, N., Pu, L., Zhang, T., and Wang, L. X., Molecular cloning, tissue expression pattern, and copy number variation of porcine SCUBE3, vol. 15, p. -, 2016.

The signal peptide CUB EGF-like domain-containing protein 3 (SCUBE3) gene is a member of SCUBE gene family and plays important roles in bone cell biology and the determination of limb bone length. In this study, the full-length transcript of porcine SCUBE3 was cloned using reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends. The full-length sequence of porcine SCUBE3 cDNA was 4131 base pairs and included 21 exons.

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