Codon 72

Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women

M. P. Gallegos-Arreola, Figuera-Villanueva, L. E., Puebla-Pérez, A. M., Montoya-Fuentes, H., Suarez-Rincon, A. E., and Zúñiga-González, G. M., Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women, vol. 11, pp. 1401-1408, 2012.

The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 Mexican women with endometriosis. The observed genotype frequencies for controls and endometriosis patients were 8 and 22% for proline/proline (Pro/Pro), 30 and 34% for proline/arginine (Pro/Arg), and 62 and 44% for arginine/arginine (Arg/Arg), respectively.

Subscribe to Codon 72