CMAP

Expression profiling analysis of hypoxic pulmonary disease

L. Zhou, Wang, L. M., Song, H. M., Shen, Y. Q., Xu, W. J., Xu, J. H., Liu, Y., Yan, W. W., and Jiang, J. F., Expression profiling analysis of hypoxic pulmonary disease, vol. 12, pp. 4162-4170, 2013.

Exposure of humans to low levels of environmental oxygen results in alveolar hypoxia and normally causes chronic pulmonary hypertension and morphological alterations of precapillary pulmonary vessels. In this study, the microarray dataset GSE11341 was used to identify potential differentially expressed genes related with human lung microvascular endothelial cell hypoxia. In addition, gene ontology term enrichment analysis was performed to explore their underlying functions. In addition, we also investigated the small molecules by comparing with the Connectivity Map.

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