Clusia alata

The mutagenic potential of Clusia alata (Clusiaceae) extract based on two short-term in vivo assays

A. C. G. Moura, Perazzo, F. F., and Maistro, E. L., The mutagenic potential of Clusia alata (Clusiaceae) extract based on two short-term in vivo assays, vol. 7, pp. 1360-1368, 2008.

We examined the genotoxic and mutagenic effects of a crude extract of Clusia alata (a potential medicinal plant) on peripheral leukocyte and bone marrow cells of mice, using the comet and chromosome aberration assays. Extracts at doses of 1000, 1500 and 2000 mg/kg were administered by gavage, and a positive control, N-nitroso-N-ethylurea (50 mg/kg) was injected intraperitoneally. Peripheral blood leukocytes were collected 4 and 24 h after the treatments for the comet assay, and bone marrow cells were collected 24 h after the treatments, for the chromosome aberration assay.

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