Cleidocranial dysplasia

Role of the RUNX2 p.R225Q mutation in cleidocranial dysplasia: a rare presentation and an analysis of the RUNX2 protein structure

L. Z. Wu, Su, W. Q., Liu, Y. F., Ge, X., Zhang, Y., and Wang, X. J., Role of the RUNX2 p.R225Q mutation in cleidocranial dysplasia: a rare presentation and an analysis of the RUNX2 protein structure, vol. 13, pp. 1187-1194, 2014.

Cleidocranial dysplasia (CCD; MIM 119600) is an autosomal dominant hereditary disorder of skeletal features whose characteristic clinical symptoms are caused by mutations in the RUNX2 gene. Varying degrees of clavicular hypoplasia and dental abnormalities are the most prominent features of this disorder. In this study, we presented a Chinese family that included 4 individuals with a p.R225Q mutation in the RUNX2 gene and characteristic CCD phenotypes.

RUNX2 mutations in cleidocranial dysplasia

K. - E. Lee, Seymen, F., Ko, J., Yildirim, M., Tuna, E. B., Gencay, K., and Kim, J. - W., RUNX2 mutations in cleidocranial dysplasia, vol. 12, pp. 4567-4574, 2013.

The runt-related transcription factor 2 gene (RUNX2), which is also known as CBFA1, is a master regulatory gene in bone formation. Mutations in RUNX2 have been identified in cleidocranial dysplasia (CCD) patients. CCD is a rare autosomal dominant skeletal dysplasia that is characterized by delayed closure of cranial sutures, aplastic or hypoplastic clavicle formation, short stature, and dental anomalies, including malocclusion, supernumerary teeth, and delayed eruption of permanent teeth.

A novel RUNX2 mutation (T420I) in Chinese patients with cleidocranial dysplasia

G. X. Wang, Sun, R. P., and Song, F. L., A novel RUNX2 mutation (T420I) in Chinese patients with cleidocranial dysplasia, vol. 9, pp. 41-47, 2010.

Cleidocranial dysplasia (CCD) is an autosomal-dominant heritable skeletal disease caused by heterozygous mutations in the RUNX2 gene. We studied a Chinese family that included three affected individuals with CCD phenotypes; the clinical features of patients with CCD include delayed closure of fontanelles, frontal bossing, dysplasia of clavicles, late tooth eruption, and other skeletal anomalies. X-ray analysis showed aplasia of the clavicles.

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