Cisplatin

Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Y. Q. Jiang, Xu, X. P., Guo, Q. M., Xu, X. C., Liu, Q. Y., An, S. H., Xu, J. L., Su, F., Tai, J. B., Jiang, Y. Q., Xu, X. P., Guo, Q. M., Xu, X. C., Liu, Q. Y., An, S. H., Xu, J. L., Su, F., and Tai, J. B., Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var., vol. 15, p. -, 2016.

Drug resistance in cells is a major impedance to successful treatment of lung cancer. Taxus chinensis var. inhibits the growth of tumor cells and promotes the synthesis of interleukins 1 and 2 and tumor necrosis factor, enhancing immune function. In this study, T. chinensis var.-induced cell death was analyzed in lung cancer cells (H460) enriched for stem cell growth in a defined serum-free medium. Taxus-treated stem cells were also analyzed for Rhodamine 123 (Rh-123) expression by flow cytometry, and used as a standard functional indicator of MDR.

Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin

W. M. Lin and Li, Z. G., Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin, vol. 14, pp. 16905-16912, 2015.

Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, “eating of self”, has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy in cisplatin-sensitivity of CC cells via blockage of cisplatin-induced autophagy.

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