Chronic superficial gastritis

Role of the IL-11/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer

D. Q. Wang, Ding, X. P., Yin, S., Mao, Y. D., Wang, D. Q., Ding, X. P., Yin, S., Mao, Y. D., Wang, D. Q., Ding, X. P., Yin, S., and Mao, Y. D., Role of the IL-11/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer, vol. 15, p. -, 2016.

The expression of interleukin-11 (IL-11) and its products STAT3 and phospho-STAT3 (p-STAT3) in patients with chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), and gastric cancer (GC) may provide insight into the diagnostic role of the IL-11/STAT3 signaling pathway in GC. Gastric mucosa specimens and serum samples were collected from 90 patients with CSG, CAG, and GC (30/group). The expression of IL-11, STAT3, and p-STAT3 was detected via immunohistochemistry and western blot. Additionally, serum levels of IL-11 were measured by enzyme-linked immunosorbent assay.

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