Chronic periodontitis

Lack of association between the vitamin D receptor polymorphism rs2228570 and chronic periodontitis in a Han Chinese population

X. Wang, Zhang, T. L., and Chen, D., Lack of association between the vitamin D receptor polymorphism rs2228570 and chronic periodontitis in a Han Chinese population, vol. 14, pp. 12299-12305, 2015.

The vitamin D receptor (VDR) is involved in the immune response and bone metabolism, both of which are implicated in the pathogenesis of chronic periodontitis (CP). In this study, we investigated the association between the VDR single nucleotide polymorphism rs2228570 and CP susceptibility in a Han Chinese population consisting of 440 moderate or severe CP patients and 324 controls. Genomic DNA was extracted from buccal epithelial cells and genotyped using matrix-assisted laser desorption/ionization time-of-flight-mass spectrometry.

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