Chronic obstructive pulmonary disease

Upregulation of ICAM-1 and IL-1β protein expression promotes lung injury in chronic obstructive pulmonary disease

Y. X. Wang, Ji, M. L., Jiang, C. Y., Qian, Z. B., Wang, Y. X., Ji, M. L., Jiang, C. Y., and Qian, Z. B., “Upregulation of ICAM-1 and IL-1β protein expression promotes lung injury in chronic obstructive pulmonary disease”, vol. 15, p. -, 2016.

Chronic obstructive pulmonary disease (COPD) is a devastating lung disorder characterized by sustained airway flow restriction that is not fully reversible. The precise pathogenic mechanisms are unknown, but it is clear that cigarette smoking and chronic inflammatory stimulation are the major causes of COPD. Lung inflammation associated with COPD involves multiple cytokines, aggregation, and activation of neutrophils in the airway and lung tissue, and release of proteases and oxygen free radicals.

Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining

L. An, Xia, H., Zhou, P., Hua, L., An, L., Xia, H., Zhou, P., Hua, L., An, L., Xia, H., Zhou, P., and Hua, L., “Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining”, vol. 15, p. -, 2016.

Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. In recent years, as one of the most widely studied genes including tests for associations between a genetic variant and COPD, epoxide hydrolase 1 (EPHX1) was found to be involved in the metabolism of tobacco smoke, an important risk factor of COPD.

Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease

C. M. Yun and Sang, X. Y., “Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease”, vol. 14, pp. 13215-13220, 2015.

We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism assay was used to assess the polymorphisms PAR1 IVS-14 A/T rs168753 and -506 I/D rs11267092.

Associations between HIF-1α polymorphisms C1772T and G1790A and susceptibility to chronic obstructive pulmonary disease

W. T. Wei, Li, B., Chen, M., Jia, H. R., and Zhang, H. X., “Associations between HIF-1α polymorphisms C1772T and G1790A and susceptibility to chronic obstructive pulmonary disease”, vol. 14, pp. 17341-17347, 2015.

In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction fragment length polymorphism was used to assess the C1772T and G1790A polymorphisms in the HIF-1α gene, and differences in genotypes between the 2 groups were compared.

Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis

Y. L. Wang, Kong, H., Xie, W. P., and Wang, H., “Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis”, vol. 14, pp. 10774-10785, 2015.

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the association between VDBP gene polymorphism and COPD. After qualitative evaluation, randomized controlled trials were pooled using either a fixed- or a random-effect model depending upon the degree of heterogeneity.

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