Chronic lymphocytic leukemia

Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles

L. Dong, Bi, K. H., Huang, N., Chen, C. Y., Dong, L., Bi, K. H., Huang, N., Chen, C. Y., Dong, L., Bi, K. H., Huang, N., and Chen, C. Y., Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles, vol. 15, p. -, 2016.

Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL samples and age-matched controls were identified using microRNA (miRNA) and mRNA expression profiles. Differentially expressed (DE) miRNA targets were predicted by combining five algorithms.

Analysis of CD38 and ZAP70 mRNA expression among cytogenetic subgroups of Iranian chronic-lymphocytic-leukemia patients

H. Teimori, Akbari, M. T., Hamid, M., Forouzandeh, M., and Bibordi, E., Analysis of CD38 and ZAP70 mRNA expression among cytogenetic subgroups of Iranian chronic-lymphocytic-leukemia patients, vol. 10, pp. 2415-2423, 2011.

Chromosomal abnormalities and ZAP70 expression profile are two major independent prognostic markers in B-cell chronic lymphocytic leukemia. We investigated a possible correlation between these two markers. ZAP70 expression using real-time RT-PCR was examined in 20 B-cell chronic lymphocytic leukemia patients with del13q14, 13 patients with del11q22, 15 patients with trisomy 12, and 16 patients with no detected chromosomal abnormalities.

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