Chromosome 1

Translocation breakpoints of chromosome 1 in male carriers: clinical features and implications for genetic counseling

R. X. Wang, Zhang, H. G., Pan, Y., Chen, S., Yue, F. G., Zhu, D. L., Liu, R. Z., Wang, R. X., Zhang, H. G., Pan, Y., Chen, S., Yue, F. G., Zhu, D. L., and Liu, R. Z., “Translocation breakpoints of chromosome 1 in male carriers: clinical features and implications for genetic counseling”, vol. 15, p. -, 2016.

Reciprocal translocation is closely associated with male infertility and recurrent miscarriages. Balanced reciprocal translocations associated with reproductive failures are predominantly observed on chromosome 1. Additionally, infertile male patients present a number of breakpoints throughout chromosome 1. A translocation breakpoint might interrupt the structure of an important gene, leading to male infertility. Here, we report the breakpoints on chromosome 1 translocation and the clinical features presented in carriers, to enable informed genetic counseling of these patients.

A framework radiation hybrid map of buffalo chromosome 1 ordering scaffolds from buffalo genome sequence assembly

N. B. Stafuzza, Naressi, B. C. M., Yang, E., Cai, J. J., and Amaral-Trusty, M. E. J., “A framework radiation hybrid map of buffalo chromosome 1 ordering scaffolds from buffalo genome sequence assembly”, vol. 14, pp. 13096-13104, 2015.

River buffalo chromosome 1 (BBU1) is a sub-metacentric chromosome homologous to bovine chromosomes 1 and 27. In this study, we constructed a new framework radiation hybrid (RH) map from BBU1 using BBURH5000 panel adding nine new genes (ADRB3, ATP2C1, COPB2, CRYGS, P2RY1, SLC5A3, SLC20A2, SST, and ZDHHC2) and one microsatellite (CSSM043) to the set of markers previously mapped on BBU1.

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