Chondroitin sulfate

Elimination of breast tumor-associated chondroitin sulfate promotes metastasis

R. D. Prinz, Willis, C. M., Viloria-Petit, A., and Klüppel, M., Elimination of breast tumor-associated chondroitin sulfate promotes metastasis, vol. 10, pp. 3901-3913, 2011.

Breast cancer is one of the leading causes of cancer-related deaths amongst women in the USA. The tumor microenvironment has been suggested to be an attractive therapeutic target for treatment of cancers. The glycosaminoglycan chondroitin sulfate, as part of the cellular microenvironment, consists of long linear chains of repeating disaccharide units, which are covalently attached to core proteins to form chondroitin sulfate-proteoglycans.

Identification and characterization of TGFβ-dependent and -independent cis-regulatory modules in the C4ST-1/CHST11 locus

C. M. Willis, Wrana, J. L., and Klüppel, M., Identification and characterization of TGFβ-dependent and -independent cis-regulatory modules in the C4ST-1/CHST11 locus, vol. 8, pp. 1331-1343, 2009.

Chondroitin-4-sulfotransferase-1(C4ST-1)/carbohydrate sul­fotransferase 11 (CHST11) is a Golgi-bound enzyme involved in the biosyn­thesis of the glycosaminoglycan chondroitin sulfate. The sulfation pattern of chondroitin is tightly regulated during development, injury and disease, with the temporal and spatial expression of chondroitin sulfotransferase genes be­lieved to be a crucial determinant of the fine balance of chondroitin sulfation.

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